Retinol Metabolism

This category contains 3 posts

Part III: Retinol Metabolism Cont’d; Why Retinol Can Never Replace Tretinoin

In Part I, we discussed an overview of retinol metabolism in the skin. It delved into the actual steps and corresponding classes of enzymes responsible for the conversion process. Part II examined and analyzed the various issues about retinol use such as: retinol strength, and concomitant use with acidic products. In this final part, we will discuss whether or not retinol can … Continue reading

Part II: Retinol Metabolism Cont’d; Retinol Degradation and Strength; Combination Use of (Hydroxy) Acids and Retinol

FAQs about Retinol In Part I, we discussed the main pathway of retinol metabolism and learned that in order to allow the skin to OPTIMALLY convert retinol into retinaldehyde, and then into tretinoin, a retinol product should have a pH value of between ~5.0-6.0. So the obvious question that is asked most often is, “Can I use retinol … Continue reading

Part I: Updated Post on the Main Pathway of Retinol Metabolism

The Main Pathway of Retinol Metabolism *Sections of this post were done on FutureDerm ( However, I wasn’t satisfied with it because the information was incomplete. So I decided to update this post with some supplementary facts and create a series out of it. **Part I will discuss just retinol metabolism. Part II will be an extension of this topic, and will be a … Continue reading

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